Dapk3 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comDapk3 Polyclonal Antibody for Mouse(Mus musculus)

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Dapk3 (Gene name),

Death-associated protein kinase 3 (Protein name ), DAPK3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dapk3(Zipk);

Protein name:

Death-associated protein kinase 3(DAP kinase 3);

Alternative:

ZIP-kinase;DAP-like kinase(Dlk);ZIP-kinase;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L.

Function:

Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.

Subcellular Location:

Nucleus Cytoplasm Chromosome centromere Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments. Associates to centromeres from prophase to anaphase.

Protein Attributes:

Sequence length:

448

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

448:

AGGLKRRLCR | LENRYDALAA | QVAAEVQFVR | DLVRALEQER | LQAECGVR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.10294

String:

O54784

STRING:

10090.ENSMUSP00000035962

Pfam:

PF00069

SMR:

O54784

KEGG:

mmu:13144

Uniprot:

O54784

FOR

ELISA Kit for Mouse DAP kinase 3

Cat.:

E15322m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse DAP kinase 3

Cat.:

E15322r

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96T

ELISA Kit for Mouse DAP kinase 3

Cat.:

E15322h

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96T

CLIA Kit for Mouse DAP kinase 3

Cat.:

U15322h

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MSDS:

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96T

CLIA Kit for Mouse DAP kinase 3

Cat.:

U15322r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse DAP kinase 3

Cat.:

U15322m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse DAP kinase 3

Cat.:

P15322Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse DAP kinase 3

Cat.:

P15322Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse DAP kinase 3

Cat.:

P15322Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse DAP kinase 3

Protein for Mouse DAP kinase 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"ZIP kinase, a novel serine/threonine kinase which mediates apoptosis."
Kawai T. , Matsumoto M. , Takeda K. , Sanjo H. , Akira S.
Mol. Cell. Biol.18:1642-1651(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;COFACTOR;FUNCTION IN APOPTOSIS;TISSUE SPECIFICITY;INTERACTION WITH ATF4;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-42; VAL-422; VAL-429 AND LEU-436
2.

"ZIP kinase triggers apoptosis from nuclear PML oncogenic domains."
Kawai T. , Akira S. , Reed J.C.
Mol. Cell. Biol.23:6174-6186(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;SUBCELLULAR LOCATION;INTERACTION WITH DAXX AND PAWR
3.

"ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts."
Komatsu S. , Ikebe M.
J. Cell Biol.165:243-254(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF MYL12B;CATALYTIC ACTIVITY;FUNCTION IN CYTOSKELETON REORGANIZATION
4.

"Physical and functional interactions between STAT3 and ZIP kinase."
Sato N. , Kawai T. , Sugiyama K. , Muromoto R. , Imoto S. , Sekine Y. , Ishida M. , Akira S. , Matsuda T.
Int. Immunol.17:1543-1552(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF STAT3;CATALYTIC ACTIVITY;INTERACTION WITH STAT3
5.

"Phosphorylation of threonine-265 in zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines."
Sato N. , Kamada N. , Muromoto R. , Kawai T. , Sugiyama K. , Watanabe T. , Imoto S. , Sekine Y. , Ohbayashi N. , Ishida M. , Akira S. , Matsuda T.
Immunol. Lett.103:127-134(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION AT THR-265
6.

"Physical and functional interactions between ZIP kinase and UbcH5."
Ohbayashi N. , Okada K. , Kawakami S. , Togi S. , Sato N. , Ikeda O. , Kamitani S. , Muromoto R. , Sekine Y. , Kawai T. , Akira S. , Matsuda T.
Biochem. Biophys. Res. Commun.372:708-712(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE2D1; UBE2D2 AND UBE2D3;UBIQUITINATION;SUBCELLULAR LOCATION
7.

"Phosphorylation-dependent control of ZIPK nuclear import is species specific."
Weitzel D.H. , Chambers J. , Haystead T.A.
Cell. Signal.23:297-303(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF 289-ARG-ARG-290 AND ALA-294
8.

"Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)."
Togi S. , Ikeda O. , Kamitani S. , Nakasuji M. , Sekine Y. , Muromoto R. , Nanbo A. , Oritani K. , Kawai T. , Akira S. , Matsuda T.
J. Biol. Chem.286:19170-19177(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NLK AND TCF7L2
9.

"Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages."
Arif A. , Chatterjee P. , Moodt R.A. , Fox P.L.
Mol. Cell. Biol.32:5046-5055(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RPL13A;CATALYTIC ACTIVITY

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